# Transport, tissue and materials

> Peptide Research Inc reading list — The Peptide Research Inc reading list: PepT1 transport, KPV in mouse colon models, hydrogels and cultured human epithelial cells.

**The reading list**

I’d begin at PepT1’s awkward double role, then return to the earlier uptake experiment. The materials studies become much more interesting in that order.

## Colon experiments involving PepT1

The [mouse colitis-associated cancer paper](https://pubmed.ncbi.nlm.nih.gov/27458604/) puts PepT1’s double role in view. The earlier [uptake study](https://pubmed.ncbi.nlm.nih.gov/18061177/) connects transport with inflammatory responses in cultured cells and colitis in mice. The separate [mouse-colitis study](https://pubmed.ncbi.nlm.nih.gov/18092346/) adds recovery, tissue inflammation and the MC1R-deficient animals.

For the family connection, the [alpha-MSH and related-tripeptide review](https://pubmed.ncbi.nlm.nih.gov/18612139/) is a useful companion. It is a review of experimental literature.

## Materials and epithelial cells

The materials sequence runs from [KPV stabilization in a hydrogel](https://pubmed.ncbi.nlm.nih.gov/34547895/) to [a double-network gel in mouse colitis](https://pubmed.ncbi.nlm.nih.gov/35245681/), with [targeted oral nanoparticles](https://pubmed.ncbi.nlm.nih.gov/28143741/) and [the KPV/FK506 preparation](https://pubmed.ncbi.nlm.nih.gov/39211778/) supplying different constructions and comparisons.

The [fine-dust keratinocyte study](https://pubmed.ncbi.nlm.nih.gov/40073467/) and [bronchial epithelial-cell paper](https://pubmed.ncbi.nlm.nih.gov/22837805/) move the investigation beyond intestinal tissue. Both concern experimental human-derived cell systems.

## References

[1] Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model https://pubmed.ncbi.nlm.nih.gov/27458604/
[2] PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation https://pubmed.ncbi.nlm.nih.gov/18061177/
[3] Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease https://pubmed.ncbi.nlm.nih.gov/18092346/
[4] Self-Cross-Linked Hydrogel of Cysteamine-Grafted gamma-Polyglutamic Acid Stabilized Tripeptide KPV for Treating Inflammatory Bowel Disease https://pubmed.ncbi.nlm.nih.gov/34547895/
[5] A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon https://pubmed.ncbi.nlm.nih.gov/35245681/
[6] Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis https://pubmed.ncbi.nlm.nih.gov/28143741/
[7] PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combination treatment of acute and chronic DSS-induced colitis https://pubmed.ncbi.nlm.nih.gov/39211778/
[8] Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation https://pubmed.ncbi.nlm.nih.gov/40073467/
[9] Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: role of KPV https://pubmed.ncbi.nlm.nih.gov/22837805/
[10] Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases https://pubmed.ncbi.nlm.nih.gov/18612139/

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I follow KPV through published research on cells and delivery materials here; Peptide Research Inc is an editorial site, offers no commercial service and gives no medical advice.