The reading list
Transport, tissue and materials
I’d begin at PepT1’s awkward double role, then return to the earlier uptake experiment. The materials studies become much more interesting in that order.
Colon experiments involving PepT1
The mouse colitis-associated cancer paper puts PepT1’s double role in view. The earlier uptake study connects transport with inflammatory responses in cultured cells and colitis in mice. The separate mouse-colitis study adds recovery, tissue inflammation and the MC1R-deficient animals.
For the family connection, the alpha-MSH and related-tripeptide review is a useful companion. It is a review of experimental literature.
Materials and epithelial cells
The materials sequence runs from KPV stabilization in a hydrogel to a double-network gel in mouse colitis, with targeted oral nanoparticles and the KPV/FK506 preparation supplying different constructions and comparisons.
The fine-dust keratinocyte study and bronchial epithelial-cell paper move the investigation beyond intestinal tissue. Both concern experimental human-derived cell systems.
- Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model ↗
- PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation ↗
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease ↗
- Self-Cross-Linked Hydrogel of Cysteamine-Grafted gamma-Polyglutamic Acid Stabilized Tripeptide KPV for Treating Inflammatory Bowel Disease ↗
- A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon ↗
- Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis ↗
- PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combination treatment of acute and chronic DSS-induced colitis ↗
- Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation ↗
- Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: role of KPV ↗
- Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases ↗